Ashland Specialty Ingredients announced a new generation of ultra pure crospovidones is now available to the pharmaceutical industry on a commercial scale.
The high-purity crospovidone, sold under the trade names Polyplasdone® Ultra and Polyplasdone® Ultra-10, will be manufactured to standards well above commercial products currently in the market.
Ashland Specialty Ingredients invested heavily in a new state-of-the-art production facility at Texas City, Texas (USA) to produce high-purity, high-quality grades of Polyplasdone Ultra crospovidone specifically for the pharmaceutical industry.
According to Philip Strenger, Senior Vice President Global Pharmaceuticals, with the launch of ultra high-purity crospovidone, the pharmaceutical industry can now use this excipient technology for a broader spectrum of drug formulations. “Formulators of pharmaceuticals have long appreciated the combined disintegrant and solubilization functionality Polyplasdone crospovidone brings to oral solid dosage formulations, and they have asked Ashland Specialty Ingredients to raise the benchmark in purity so it can be formulated in conjunction with virtually every drug active,” he said. “Beginning in November, Ashland Specialty ingredients will offer samples of Polyplasdone Ultra and Ultra-10 crospovidones manufactured on commercial-scale, fulfilling the pharmaceutical industry’s request for the next generation of crospovidone with a purity profile that will allow for use in some of the world’s most sensitive APIs. This is a further step in strengthening the Ashland Specialty Ingredients tool kit for increasing the bioavailability of poorly soluble actives,” he added.
Advancing the science of coatings – Advantia Preferred HS coatings
In addition to offering Advantia Prime coatings based on conventional cellulosic polymers, Ashland Specialty ingredients is developing innovative coatings based on its experience as a leading polymer research company.
The Ashland Specialty Ingredients technical team has core strengths in design and development of novel functional systems
based on molecular structure-property relationships and a leader in polymer research.
Advantia Preferred HS coatings give you high quality coatings in record time. The product of Ashland Specialty Ingredients’ extensive experience as a leader in polymer research, Advantia Preferred HS coatings are specially designed to be applied at high solids concentrations. This allows the coating to be deposited faster
than a conventional coating, which improve processing time significantly. Production-scale coating
trials conducted by Ashland Specialty Ingredients have demonstrated that spraying Advantia Preferred HS coating suspensions
at up to 25% solids translates into a 43% savings in process time over traditional HPMC-based coating suspensions (Figure 1)
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